Brain Segmentation and Structural Multiparametric Analysis for Cortical Malformations Detection in Focal Epilepsy

F. Cervenansky, D. Dufournel, N. Costes, P. Ryvlin, D. Sappey-Marinier CERMEP, Université Claude Bernard, Lyon, France, CERMEP, CNRS, Lyon, France, Neurology hospital, Lyon, France Synopsis With the advent of high resolution MRI, malformations of cortical development (MCD) are increasingly detected and recognized as the underlying cause of seizure in patients with intractable focal epilepsy. Processing tools including brain extraction, tissue classification and structural multiparametric analysis (SMA) are developed to enhance MCD detection on conventional MRI. The SMA application on five T1w-MRI patients point out MCD lesions that are undistinguishable from normal gray matter.